Benzoyl Peroxide: What It Does, How It Works, and What Alternatives Exist

When you’re dealing with stubborn acne, benzoyl peroxide, a topical agent used to treat acne by killing bacteria and reducing oil and dead skin buildup. Also known as BPO, it’s one of the most widely used over-the-counter acne treatments in the world. It doesn’t just dry out your skin—it attacks the root cause: Cutibacterium acnes, the bacteria that triggers inflammation in clogged pores. Unlike some treatments that only smooth the surface, benzoyl peroxide actually reduces the number of acne-causing microbes, which is why it’s often the first thing dermatologists recommend.

It’s not the only option, though. People who switch to azelaic acid, a naturally occurring acid used to treat acne and rosacea with anti-inflammatory properties often do so because benzoyl peroxide can be too harsh—especially for sensitive skin. Others try podophyllum resin, a plant-based compound used in wart removal and sometimes in acne creams for its keratolytic effects, though it’s not meant for daily use like benzoyl peroxide. Then there’s crotamiton, a topical antipruritic used mainly for scabies but sometimes repurposed for acne due to its soothing effect, which doesn’t kill bacteria but can calm redness. Each of these has its place, but none work the same way benzoyl peroxide does: fast, direct, and targeted.

If you’ve tried benzoyl peroxide and got irritated skin, you’re not alone. Many users stop because of dryness, peeling, or burning—not because it doesn’t work, but because they didn’t start slow. The key isn’t to use more of it, but to use it right: start with a 2.5% gel once a day, let your skin adjust, then increase only if needed. Pair it with a gentle moisturizer, and avoid using it with other strong actives like retinoids until your skin builds tolerance. It’s also important to know that benzoyl peroxide bleaches fabric, so watch your pillowcases and towels.

What you’ll find in the posts below isn’t just a list of products—it’s a real-world look at how people manage acne with and without benzoyl peroxide. You’ll see comparisons between it and other topical treatments, stories about side effects, and insights into when to skip it entirely. Whether you’re new to acne treatment or you’ve been fighting breakouts for years, these guides give you the facts without the hype.