Diclegis: What It Is, How It Works, and Alternatives for Morning Sickness

When you're pregnant and sick to your stomach all day, Diclegis, a prescription medication combining doxylamine and pyridoxine specifically approved for nausea and vomiting during pregnancy. Also known as doxylamine-pyridoxine, it’s one of the few drugs backed by the FDA for this use—and it works for many women when other remedies fail. Unlike herbal teas or ginger candies, Diclegis delivers a precise, tested dose of two ingredients that have been used safely for decades to calm the nausea signals in the brain and digestive tract.

It’s not the only option, though. Many women try doxylamine, an antihistamine found in over-the-counter sleep aids like Unisom on its own, or pair it with vitamin B6, which is exactly what Diclegis does—but in a controlled, timed-release form. Then there’s pyridoxine, the active form of vitamin B6, which helps regulate neurotransmitters linked to nausea. Together, they reduce symptoms without crossing the placenta in harmful amounts. But not everyone responds the same. Some feel better in days. Others need to try different doses or switch to alternatives like Zofran or Bonine, especially if they’re dealing with severe morning sickness—hyperemesis gravidarum.

What’s missing from most conversations is the real-world experience: the cost, the insurance battles, the side effects like drowsiness that make driving risky, and how hard it is to find a doctor who knows how to prescribe it right. That’s why the posts below dive into what works, what doesn’t, and how other women have managed nausea without turning to risky or unproven fixes. You’ll find comparisons with other treatments, stories from people who tried everything, and practical advice on how to get the most out of Diclegis—or when to walk away from it.